Joe Gomez is facing a battle to play again this season after undergoing knee surgery this morning.
But Liverpool have not given up hope of him featuring again in this campaign.
The Kop defender suffered the serious injury during training for England on Wednesday.
Gomez, 23, was preparing for the Three Lions' clash with the Republic of Ireland when he went down on the training pitch.
He underwent scans early this morning and the club have now confirmed he has undergone successful surgery on a tendon in his knee.
It is understood he has not suffered any ligament damage.
The Reds are not putting a timescale on his return but they are refusing to rule him out for the remainder of the campaign.
England boss Gareth Southgate said on Wednesday soon after the incident that he hoped it wouldn't be long term but that looks now to be the case.
"There was nobody around him when the injury happened. I didn't like that element of it," said Southgate.
“We're hopeful for him that it's not what it might be, but it's not a good situation.
“My immediate thoughts are with him because he's had some difficulties with injury in the past.
“We're hoping and praying that it's not going to be a long-term one, but we just have to see.”
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His absence is a huge blow for Kop boss Jurgen Klopp who is already without Virgil van Dijk after he also went under the knife for a knee injury.
Van Dijk is also fighting to play again this season while Joel Matip has just returned from a knee problem of his own.
Liverpool are now left with just Matip as their only recognised fit senior centre-half although Nathaniel Phillips and Rhys Williams have featured in the position in recent weeks.
Fabinho, who has been used as a makeshift centre-back, is also battling to return to fitness in the coming weeks.
Right back Trent Alexander-Arnold is also out for four weeks after suffering a calf injury in their recent 1-1 draw with Manchester City.
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