Liverpool will be without Sadio Mane, Mohamed Salah and Naby Keita for up to a month of the 2021/22 Premier League season.
The Reds will be looking to regain the league title after an injury-hit campaign, which saw Jurgen Klopp's side lose their way in dramatic style.
Klopp's men kick-off next season with a favourable list of fixtures, including Norwich City, Burnley and Brentford in the fist six games.
But the Reds will lose Mane, Salah and Keita due to the African Cup of Nations taking place, with the trio representing Egypt, Senegal and Guinea respectively.
The tournament will take place between January 9 and February 6 2022 – one year later than scheduled due to coronavirus fears.
Liverpool are involved in two Premier League fixtures within this four-week period, hosting newly-promoted Brentford on January 15 before making the trip to Selhurst Park to face Crystal Palace on January 22.
One other fixture the trio are set to miss will be the third-round of the FA Cup, which is due to be played on the weekend of January 8 and 9.
The previous AFCON, held in 2019, took place between June and July and benefited Liverpool greatly due to no fixtures being missed, though the same can't be said for the 2017 tournament.
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Mane missed a total of seven games for Liverpool during the 2017 AFCON, with the Reds involved in key EFL Cup FA Cup and Premier League contests.
When planning for the 2021 tournament in late 2019, the organisers of the event took the decision to move it from the summer to the winter because of the warm climate in the host nation of Cameroon during June and July.
Klopp reacted badly to this news in January 2020, telling reporters:
"The African Cup of Nations going back to January is, for us, a catastrophe.
“We will not sell Sadio, Mo or Naby now because they have a tournament in January and February – of course not. But if you have to make a decision about bringing in a player, it is a massive one because before the season you know for four weeks you don’t have them.
"That’s a normal process and as a club you have to think about these things.”
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