Manchester United are expected to name an unchanged side as they look to stretch their winning run to five games against Southampton.
The Red Devils have scored 14 goals in their last four games, breaking Premier League records as they chase the top four.
Ole Gunnar Solskjaer's side will again look to pick up the three points against a Southampton side who recently beat Manchester Cuty.
The Saints have little to play for this season but will come up against a relentless United side playing some excellent football.
Bruno Fernandes has been at the heart of that and again scored in their recent win at Aston Villa.
He will continue to be part of a three-man midfield that includes Paul Pogba and Nemanja Matic.
Solskjaer is also expected to continue with the same front three that have caused defences all kinds of problems.
All eyes will again be on Mason Greenwood who scored for the fourth time in three games at Villa Park.
Much has been made of the teenager's rapid rise with his goal tally now up to 16.
And Solskjaer admits the sky is the limit for the 18-year-old.
“I am doing my bit to help him but he has to do it – turn in performances in training, in games, live his life properly, it’s up to him how far he wants to go,” he said.
“He’s 18, of course he will get better. He is a natural footballer, has been in the academy since he was a little boy, his dad showed me a picture of us when he was seven.
"He knows we believe in him. You cannot leave players out when they score goals.”
The Norwegian is also expected to pick the same back five that have kept three clean sheets in their past four outings.
Man Utd: (4-2-3-1): De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Matic, Pogba; Greenwood, Fernandes, Rashford; Martial
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