Anthony Martial is back available and should return to the starting XI. Axel Tuanzebe, hero of Paris, could also return but Paul Pogba looks likely to miss out once again.
New boy Donny van de Beek is pushing for inclusion and could play if Bruno Fernandes is rested ahead of Arsenal.
The visitors will be without Lukas Klostermann, Nordri Mukiele, Konrad Laimer and Amadou Haidara.
Manchester United: De Gea, Tuanzebe, Lindelof, Maguire, Wan-Bissaka, McTominay, Fred, Telles, Fernandes, Rashford, Martial
RB Leipzig: Gulacsi, Orban, Upamecano, Adams, Halstenberg, Nkunku, Olmo, Forsberg, Kampl, Angelino, Poulsen
Leipzig are a quality side and will present United with significant problems. That said, United delivered on the biggest stage last week against PSG and will be hopeful a similar level of performance can bring with it an equally positive result. Manchester United 2-1 RB Leipzig
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