They've contested a Champions League final before, but there is a sense that control of this season's Premier League title race could be on the line when Liverpool and Tottenham meet at Anfield.
With the pair sitting level on 25 points each, and other clubs around them seemingly addicted to slipping up, both sides will know that a win here would give them a huge chance of being top on Christmas Day, something that Liverpool will crave as they seek to defend their title.
The Reds have both a strong home record against Spurs and a strong home record full stop, but there is nothing that Jose Mourinho loves more than pooping a Liverpudlian party.
So how will it play out in front of 2,000 fans at Anfield?
We asked some of Mirror Football's best and brightest what they think.
Liverpool 1-1 Tottenham – Neil McLeman
Tottenham will be happy with the draw tonight and expect a Jose Mourinho defensive masterclass at Anfield like in his Chelsea days.
Admire his football or not, it is undeniable that a reinvigorated Mourinho is good for the soap opera of the Premier League.
Just when you thought this title race could not get any more intriguing, there now promises to be a running verbal battle between the Spurs boss and Jurgen Klopp.
Liverpool 2-1 Tottenham – Neil Moxley
Cracks in Liverpool's cloak of invincibility have opened up. Injuries, a hectic work-load and slight dip from their imperious best of last season have shown Jurgen Klopp's dressing-room is populated by mere mortals, after all.
Spurs might scent blood. They are flying high, have a strong dressing-room and are becoming more difficult to score against. It's a recipe for success, particularly if their goalscorers remain fit.
However, even though chinks in the Reds' armour are evident – they aren't on show at Anfield.
It's going to take some performance to change that. And, for all the fact they go there with high hopes, I'm not sure Spurs are at that level…yet.
Liverpool 0-0 Tottenham – Alex Milne
Sorry to be the bearer of bad news, but I cannot see past a bore draw in a game which both coaches will be more focused on not losing than winning.
We have seen it before from the two managers, and I expect a similar cat-and-mouse encounter that we saw in Tottenham's recent goalless draw with Chelsea.
I would love to be proved wrong, but I just don't see either sides taking any unnecessary risks, and that could lead itself to a cagey match.
Both Klopp and Mourinho will feel satisfied to come out of the game with a point.
Liverpool 1-2 Tottenham – Conor Mummery
Anfield has not been a happy hunting ground for Tottenham in recent years, but Spurs are a different animal under Jose Mourinho.
There's been a change in approach to the big games away from home under the Portuguese boss, a team that under Mauricio Pochettino would try and match you blow for blow will sit firm, absorb pressure, and counter with deadly precision.
Spurs are unbeaten against the Big Six this season and Harry Kane and Heung-min Son will fancy their chances of inflicting plenty of damage on what will likely be another makeshift Liverpool defence.
Liverpool 1-1 Tottenham – David McDonnell
Jose Mourinho will set his Tottenham side up not to lose at Anfield and to frustrate Liverpool's attack, with the hope of catching them on the break if possible.
But a point at the home of the champions would be a hugely satisfying result for Mourinho and Spurs, and conclusive proof of their title credentials.
Liverpool will be looking for an immediate response following their 1-1 draw at Fulham, but expect Spurs to nullify their attack and effectively kill the game to leave with a point, rather than nothing.
Liverpool 2-1 Tottenham – Mark Jones
Liverpool rarely play poorly for two games in a row under Klopp, and the performance at Fulham is likely to sharpen minds and focus ahead of this one.
Spurs aren't a surprise these days. You know exactly what they are going to do and you know that they are going to do it very well.
They'll defend as deep as the River Mersey, but Liverpool are hugely adept at switching the play via the two full-backs, and when they don't get around you they can often just go through you with swift interplay around the box.
The visitors might even take the lead, but I'd back Liverpool to prevail in the end in a match in which fatigue is going to be a big factor.
It clear that Liverpool's minds have been on this game for a while, and that usually spells bad news for the opposition.
What's your prediction for Liverpool vs Tottenham? Have your say in the comments below
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