That leaves manager Carlo Ancelotti without three of his key players as midfielder Allan is also out with a hamstring problem.
The Italian had spoken earlier this month about having to rest Dominic Calvert-Lewin, who has started every Premier League match and played the majority of minutes in each.
After his hot streak at the start of the season, the newly-capped England international has not scored in four matches but with Richarlison and Rodriguez out there is even greater emphasis on his qualities as chances have been few and far between recently.
“It is really difficult but we have to adapt to this,” said Ancelotti.
“It is a busy period, we have to manage injury and players do tire but we have a squad and we are able to manage this and for all the teams it is the same.”
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